Monday, 16th February 47th Lorne Genome Conference 2026

• The genetic mechanisms underlying mammalian germline and somatic evolution - Duncan Odom
• Single cell transcriptional profiling of primary trabecular meshwork cells uncovers genetic drivers of glaucoma. - Alex W Hewitt
• Adipose Tissue Cellular Plasticity Distinguishes Healthy from Unhealthy Obesity: A Multi-Modal Genomics Approach - Isabel Reinisch
• Exploring the use of antisense oligonucleotides to ameliorate DNA methylation deficiencies in models of Tatton-Brown-Rahman syndrome - Hannah K Vanyai

• EmbryoRadar – a machine learning model to uncover the impact of developmental transcriptional program reawakening in cancer - Tongtong Wang
• Pre-ranked GSEA is hugely anticonservative but can be fixed. - Waruni Abeysekera
• Combinatorial Multivariate Epigenomic Patterns Reveal The Genomic Basis Of Cell Phenotypes Underpinning Complex Traits And Disease - Woo Jun Shim
• DOMINO: Diffusion-optimised graph contrastive learning framework for domain detection in spatial transcriptomic - Nora W Liu
• Discovery and visualisation of rare splice junctions at scale with LemonSplice - Andrew Lonsdale
• Integrated short- and long-read transcriptomics uncovers extensive splicing alterations in motor neuron disease cerebellum - Natalie Grima
• Detecting somatic mutations in rare clones using single cell multi-omics - Rhys Gillman

• Nanobody-Assisted Bridging of Correlative and Functional Epigenetics - Emanuel Gasser
• Mechanisms of chromatin remodelling by MORC family ATPases - Shabih Shakeel
• 3D genome remodelling underlies PU.1-dependent granulocyte maturation. - Wendy Jia
• SMCHD1 has distinct roles in gene regulation in the embryonic and adult olfactory systems - Andres Tapia del Fierro
• Developmental Roles of Non-canonical DNA Methylation at Satellite DNA Repeats - Thirsa Brethouwer
• Dynamics of embryonic DNA methylation in an Australian marsupial - Allegra Angeloni
• Looking at epigenetic regulation of virus-specific CD8+ T cell differentiation through different lenses. - Stephen J Turner

 Career Development: This year, rather than an in person event, you get to spend your lunchtime in the Genome Conference community and still invest in yourself! All delegates get access to virtual training and a confidential 1:1 session with Thriving in STEM Coach El Leithold. Just scan the code and book a time, available until 1 March 2026.

• The menagerie of matrix factorization methods - Matthew Stephens
• Beyond the gene: transcript-isoform dysregulation as a key contributor to human brain disorders - Michael Gandal
• Developmental regulation of globin genes from “bench to bedside and back” - Mitchell J Weiss
• Refate identifies chemical compounds targeting gene regulatory networks for cell-fate conversion - Katherine G Zyner

• Integrated Single-Cell Chromatin Accessibility and Gene Expression Profiling Reveals Regulatory Programs in Acute Myeloid Leukemia - Reza Mr Ghamsari
• Challenges in developing a novel screen to identify 3D genome architecture regulators - Wendy Jia
• Capturing genome-wide dynamics of bivalent chromatin in breast cancer   - Eleanor Glancy
• Vascular endothelial growth factor signalling is a gatekeeper of haematopoietic stem cell development - Alexander Maytum
• A novel biosensor to identify regulators of individual and combinatorial histone modifications in live single cells - Dian Kwang
• Exploring an epigenetic approach towards treatment for the genomic imprinting disorder Prader-Willi Syndrome - Megan Iminitoff
• INTS6 and INTS6L not your common paralogues - Sarahi Rivera
• Understanding the delivery of an ASO therapy for epidermolysis bullosa - Muhammad Ahmed
• Reconstructing pedigrees from identity-by-descent for disease gene discovery - Lyndal Henden
• Three-dimensional genome architectural and regulatory network changes define blood stem cell ageing - Quinn Stacpoole
• TNT reprogramming corrects X inactivation in human female induced pluripotent stem cells - Andrew Keniry
• Characterising the distribution and sequence composition of ZFHX3 GGC repeat expansions in ALS  - Zoe Zussa
• Long-Read Single-Cell Transcriptomics Illuminates Isoform Programs in Brain Development - Sefi D.J Prawer
• A single-cell multi-omic atlas of human primary immunodeficiencies identified cell type defects associated with poor vaccination responses - Davide Vespasiani
• Chromatin remodelling activates endogenous retroviruses (ERVs) to trigger viral mimicry in CDK4/6 inhibitor resistant breast cancer - Daniel Thomson
• Defining Nannarin biosynthesis: Genomics in an endangered species - Arnab Singha Mahapatra
• Elucidating RNA isoform expression in the 2-day old human prefrontal cortex at single-cell resolution - Marcus R Camilleri
• On the origin of sex differences in gene regulation - Shanie Landen
• Transient loss of the tumor suppressor crebbp reshapes T-cell fate and anti-cancer immune responses - Aleen Al Halawani
• Biomarker and Therapeutic Potential of Circular RNAs in Ovarian Cancer - Sineth Wijekoon Mudiyanselage
• Considering sex and sex differences in clinical research: a systematic review - Janelle Ryan
• Dynamic transcriptome-scale RNA-targeting with Cas13 - Dáire Gannon
•  Exploratory framework for genotype-phenotype prediction - Muhammad Muneeb
• Identification of Novel Candidate Variants in Disorders of Sex Development Using Whole-Genome Sequencing - Shirin Moradi Fard
• Deciphering the genetic causes of autoimmunity: from non-coding GWAS variants to target genes - Viacheslav A. Kriachkov
• Identification of de novo LTR retrotransposon insertions arising during mouse embryonic development - Alexander L Carleton
• High-resolution mapping of chromatin architecture in human osteoclasts using Micro-C to link non-coding GWAS variants to gene regulation - Dhanya Sooraj
• Retrospective single cell lineage tracing with expressed somatic mitochondrial variants - Cal McCrimmon
• Co-visualization of G-quadruplexes and i-Motifs in breast cancer cells - Melissa Foong
• Hormone-Driven Muscle Adaptation in Transgender Individuals: A Multi-Omic Dissection from the GAME Study - Bernadette Jones-Freeman
• MAP3K7 as a candidate gene for syndromic DSD: three new cases report with novel variants identified by whole exome sequencing - Vincent Harley
• Ancestral and environmental diversity shape the adaptive immune landscape in Indonesia - Irene Gallego Romero
• The BET family of histone code readers modulate CHD4 chromatin remodelling activity - Lucien Lambrechts
• Enabling long-read single-cell proteogenomics with GenomeProtSC - Ching Yin Wan
• Molecular profiling of Tasmanian Devil facial tumour vulnerabilities using whole genome CRISPR screening  - Jasmine Kaur
• Removing contamination from image-based spatial transcriptomics data with DenoIST - Davis J McCarthy
• Identifying novel targets for intervention through multi-omics studies in brain tissues of individuals with Prader-Willi syndrome - Shokouh Shahrokhi
• Decoding Fibroblast Plasticity in Skin Regeneration and Fibrosis     - Muhammad Ahmed
• Investigating the causality of genetic variants driving splicing changes using CRISPR-Cas9 base-editing - Michael Gitonobel
• Decoding genome awakening during seed germination using single-cell analysis, multiomics and spatial transcriptomics - Mathew G Lewsey
• Experimental analysis of the genomic determinants of tissue-specific splicing     - Shourya Giri
• How do chromatin readers modulate the activity of chromatin remodellers? - Clement CL Luong
• Beyond the Paradigm: When Foundations Aren’t Enough for Spatial and Single-Cell Omics - Hamid Alinejad Rokny
• Exploring the Efficiency of Multi-Target Editing of Variants implicated in Bone Marrow Failure Syndromes with Single Base Editors - Kirsten Fairfax
• Dissecting the roles of Nr6a1 at early stages of the mouse hindlimb development - Masoud Baghi
• Quantitative imaging of chromatin compaction versus access on a nanoscale in a living cell   - Elizabeth Hinde
• The molecular choreography of epigenetic enhancer remodelling in early human development - Adrienne E Sullivan
• Point mutation in a histidine to glutamate catabolic enzyme modulates behavioural adaptation to environment - Andrew D Johnston
• From bottleneck to pipeline: Robotic EM-seq processing for population-scale methylome profiling - Daniel Poppe
• Genome evolution of asexual reproduction in New Zealand stick insect hybrids - Tithi Gandhi
• Molecular dissection of cellular response to deadly Irukandji venom - Matthew A Waller
• TTN missense variant affecting a conserved Ig-domain residue as a cause of familial dilated cardiomyopathy - YuChen CC Chang
• CRISPR-screen Links FBXW11 as a Regulator of Brain Organoid Size and Neuronal Maturation Programs. - Cesar Moreno
• Single molecule tracking of homologous histone methyltransferases SUV39H1 and SET-25 - Natalya Frolows
• Identifying human cell factors mediating potato toxicity - Mathew MS Samuel
• More than a C. elegans methyltransferase: uncovering alternate pathways for H3K9me3 deposition in epigenetic inheritance - Jessica Hawes
• Viral structurome and epitranscriptome as therapeutic targets - Vincent Corbin
• Integrated CRISPR activation and knockout screens with single-cell profiling in CD4+ T cells - Maximilian Jordan
• mRNArchitect: a toolkit for the design of mRNA sequences - Helen Gunter
• Genomics Infrastructure to Support Australian Researchers - Tiff Nelson
• Capturing long-term hippocampal development in vitro using a novel stem cell-derived 3D brain organoid model system - Maria Giovanna Garone
• Investigating the role of NSD1 in the pathogenesis of Sotos syndrome using brain organoids - Vallari Sawant
• Zbtb48: a role for telomere dynamics in long-term chronic pain. - Hannah Scarborough
• DNA methylation reveals hidden cis-regulatory elements beyond chromatin accessibility during human development - Hengbin Gao