Tuesday, 17th February 47th Lorne Genome Conference 2026

• Regulation of Heterochromatin - Bing Zhu
• A story of fat mice and motivated humans – and why weight loss might not be that simple - Ferdinand von Meyenn
• The passage of epigenetic information through the germ line - Petra Hajkova

• Multi-modal functional transcriptomics reveals isoform-specific and epitranscriptomic regulation by oncogenic lncRNAs - Martin A Smith
• Robust transcriptional homeostasis of RNA polymerase II - Alexander Gillis
• TREX-2 acts as a stationary mRNA export receptor at the nuclear pore. - Yoona Kim
• Revealing gene isoforms in the developing brain: insights into neuropsychiatric disorder risk - Anran Li
• Genetic variation and tissue-specific splicing: Insights from a million GWAS study - Aaryan Mr Chhabra
• Repeat associated non-AUG initiated Translation in C9orf72 FTD/ALS: How it starts - Peter K Todd
• Investigating the role of mRNA transcript diversity in therapy-induced plasticity in melanoma - Lorey Smith

• Chronic corticosterone supplementation alters sperm DNA methylation and hydroxymethylation in exposed mice and their male offspring - Coralina Collar Fernández
• Activity-dependent gene regulation in cortical neurons relies on the 3D genome structure mediated by SATB2 - Nico Wahl
• BRCA1 vs. 53BP1: Balancing Chromatin Structure and Mobility in DNA Repair - Jieqiong Lou
• H3.3 K27M disrupts neural differentiation through loss of H3.3 serine 31 phosphorylation and aberrant KDM4B activity - Hsiao PJ Voon
• Deterministic principles and global chromatin organisation of ageing mammalian cochlea. - Alexey V Terskikh
• In memory T-cells the quiescent immune system is held in a state of readiness by an ETS1/TCF1 homeostasis gene regulatory network which is silenced during reactivation by TCR signalling. - Peter Cockerill
• Polycomb-based epigenetic memory underlies the irreversibility of p16-mediated cell cycle exit - Hongpei Li

Roche-SBX for Paired Tumour–Normal Whole Genome Sequencing

Speaker:
Joep de Ligt

Dr Joep de Ligt holds a PhD in Molecular Life Sciences with expertise in genomics and bioinformatics. He currently leads data activities at the Hartwig Medical Foundation in the Netherlands.

He has led and advised national and international genomics initiatives across human and pathogen genomics and played a key role in implementing same-day genome sequencing during the COVID-19 response in Aotearoa New Zealand. His work focuses on translating complex genomic data into actionable insights for human health.

• Conserved principles of genetic networks revealed through global mapping of genetic interactions in yeast and human cells - Brenda Andrews
• Programming gene expression in plants - Jennifer A. N. Brophy
• The levels of background transcription and splicing in the human genome - Austen Ganley

• 'Targeting the epigenome to overcome cancer immunotherapy resistance' - Marian Burr
• The Control of Transposable Elements for Genome Engineering in Plants - Keith Slotkin
• Chromatin Associated RNAs Orchestrate Cell Type Specific Gene Regulation - Hazuki Takahashi
• Cryptic polygenic adaptation in the body mass of wild meerkats - Jenny Tung

Now at The Peak - change of venue due to fire warning

Address: 2 Holliday Road, Lorne