Chromatin-modifying enzymes are key regulators of transgenerational epigenetic inheritance, but it remains unclear exactly how these enzymes scan the genome to select regulatory regions and establish these transgenerational marks. SUV39H1 and SET-25 are the respective human and worm H3K9me3 methyltransferases playing key roles in heterochromatin regulation, epigenetic inheritance and many other crucial processes but little is known about their dynamic movement within the nucleus. We are establishing a HaloTag based real-time imaging system to visualise the movement of individual proteins within live cells, animals and developing embryos. Using this system we have identified key residues within these enzymes that are necessary for functional genomic scanning and chromatin binding. Histone mark based Microscopic Imaging of Epigenetic Landscapes (MIEL) also indicates that the chromatin binding ability of these enzymes may have a significant impact on overall chromatin structure within the nucleus.